About us

We are an academically focused clinical research institution based at Northwest Hospital and University Cancer Center (UCT) Frankfurt, Germany. Focused on cutting edge, investigator-initiated cancer research, we provide clinical researchers with a high-end, completely scalable (from full-service to tailor-made selection of tasks), independent, and professional platform for planning and conduct of scientifically motivated clinical research. Furthermore, we offer a broad spectrum of solutions and services to small biotech and start-up companies in university environments to support them in developing their innovative anticancer drugs. Our mission is to advance scientifically motivated clinical and translational research on cancer and help delivering answers to current and future important clinical questions in this field

20+

Years of
Experience

5K+

Patients
in Trials

300+

Clinical
Centers

Research

Clinical Research

Excellence In Research

The objective for our research activities is clearly set: Facilitate excellent clinical cancer research at international level to improve the treatment and quality of life of patients suffering from cancer.We are not a pharmaceutical company and therefore our real ‘product’ is the gain in scientific knowledge. This is achieved by clinical trials that focus on endpoints relevant to patients such as response rate, survival and quality of life.

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Translational Research

Translational research is an important component of our study designs. Wherever possible, we collect materials to help researchers gaining a better understanding of pathogenesis and development of cancer. Currently we are participating in several projects and work with TR initiatives like the German Cancer Consortium (DKTK).

Precision Oncology

In help our academic partners improving personalized cancer therapy by establishing large networks for molecular profiling. IKF is the home of several networks including:

- PLATON for gastrointestinal Cancer

- PARAGON: Platform for Outcome, Quality of Life and Translational research on Pancreatic Cancer

- GISAR: German Sarcoma Registry

Excellence In Research

The objective for our research activities is clearly set: Facilitate excellent clinical cancer research at international level to improve the treatment and quality of life of patients suffering from cancer. We are not a pharmaceutical company and therefore our real ‘product’ is the gain in scientific knowledge. This is achieved by clinical trials that focus on endpoints relevant to patients such as response rate, survival and quality of life. Our mission is to design and successfully conduct such studies in close cooperation with our scientific partners. In our work we emphasize clinical relevance and providing answers to long-standing clinical questions to make sure our studies provide improvements to the everyday life of patients. Emphasis On IITs Or Early Clinical Research

IITs

To accomplish this, we rely on our extensive and long-standing experience in the field of investigator-initiated trials (IITs), which have been and always will be a focus of our work. Therefore, IKF Klinische Krebsforschung GmbH is often the sponsor of phase I to phase III IITs with internal or external lead investigators who are among the best experts in their fields, worldwide. Some of our studies have changed standards of care around the globe, e.g. for patients suffering from stomach or esophageal cancer. A fact which we remain to be very proud of.

Early Clinical Research

Within the last decades, we accumulated profound expertise in designing and conducting early clinical trials, including first in man studies, specifically on immunotherapeutic agents and targeting drugs. For the conduct of early clinical trials, we partner public research institutes or excellent start-up biotech companies who proved to have promising compounds and mutually develop their drugs until approval or successful out-licensing.

Services

Our Services For Academia, Pharma And Biotech

As an Academic Research Organization (ARO), we provide clinical researchers with a high-end, completely scalable (from full-service to tailor-made selection of tasks), independent, and professional platform for planning and conduct of scientifically motivated clinical research. Furthermore, we offer a broad spectrum of solutions and services to small biotech and start-up companies in university environments to support them in developing their innovative anticancer drugs.
Specifically for industry partners this can encompass the development- and life cycle of a drug. Based on our pronounced academic focus, our projects always emphasize the scientific interest in development and approval of novel therapy concepts. Our partners benefit from the sound scientific background of our staff as well as from our excellent network and widespread acceptance within the international clinical cancer research community.

300 Clinical Centers And Strong Partners

During the implementation of study concepts, we can carry out all project management, planning and operative tasks ourselves. In this we can rely not only on our longstanding and proven network of about 300 cooperating clinical centers for phase II/III studies, but also on our partnership with the Institute of Clinical Cancer Research based at Northwest Hospital and the University Cancer Center (UCT) Frankfurt. With the latter we have at our disposal a trial center of the highest clinical quality and its own phase I unit and highly qualified team of study managers, investigators and study nurses for early phase trials. The Institute of Clinical Cancer Research is part of the University Cancer Center Frankfurt (UCT).

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Implementation of complex studies like studies using multi modal or interdisciplinary therapy approaches or studies with special forms/routes of study medication administration

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Specialized (oncological) phase I unit in cooperation with Northwest Hospital

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Access to the functional units of Northwest Hospital, e.g. endoscopy, intensive care or surgery

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Established network of more than 300 medical institutions and the largest study groups for multicenter studies

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Strong scientific and medical background

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Study related processes in accordance with AMG (German medicines act) and ICH-GCP

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Project design and development, budget control and assistance when applying for research funds and grants

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(Risk-based) onsite monitoring

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Safety: SAE management, SAE second assessment, annual safety report / development safety update report (DSUR), regulatory reporting, etc.

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Medical review and electronic/manual data cleaning

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Excellent medical expertise in the development and design of clinical trial protocols, statistical analysis, synopses, patient information, informed consent forms, electronic and paper bases CRFs, operating- and process procedure descriptions

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Reporting and publishing

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Data management and statistics

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Product positioning

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Consulting of market launch and market authorization

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Benefit assessment (AMNOG, GBA)

The following Quality management components are established: SOPs; Training/Education; Reviews & Audits; Vendor Qualification ; Monitoring & Co – Monitoring; Regular risk assessment ; Contact to Authorities; CAPA

Management

Prof. Dr. med. Salah-Eddin Al-Batran

Managing Director

Office:

Anke Szramek-Pausch
Personal Assistant to the Managing Director
Tel +49 69 76 01 44 20
Fax +49 69 76 01 36 55
E-Mail: Info@ikf-khnw.de

PD Dr. med. Thorsten Götze

Senior Medical Officer

Dr. rer. nat. Daniel Müller

Lead Project Manager

Dr. rer. physiol. Claudia Pauligk

Lead Project Manager

Dr. rer. nat. Dennis Castor

Senior Scientific Consultant
Lead Quality Assurance Unit

Staff

Over the span of several years our work has earned us an excellent reputation in the field of oncology studies. But this is not solely a consequence of the groundbreaking scientific results we could achieve in close cooperation with our research partners. We owe our success largely to the extraordinary efforts, smartness, and sense of responsibility among our employees. Our staff is dynamic, multidisciplinary and highly experienced. The background of our employees often comprises a high degree (PHD or professor) in medical or natural sciences. Beside medical professionals, our team comprises biologists, a human biologist, bioinformaticians, data mangers, monitors (clinical research associates), statisticians, chemists, and an epidemiologist. Members of our staff aim to form sustainable and long-term professional relationships with our partners. That enables us to meet challenges effectively. Our partners benefit from this approach as well as from the professional expertise, the sound scientific background of our employees and their excellent network and acceptance within the scientific community.

Phase-I Unit

Our cooperating phase I unit at Northwest Hospital in Frankfurt/ University Cancer Center Frankfurt offers up to 12 in- or day patient beds with full access to the intensive and emergency care units. Most patients, who are treated in our phase I unit participate in phase I trials, but also phase II or phase III participants may be treated in the phase I unit in case of very complex trial procedures. The phase I unit is part of the University Cancer Center Frankfurt (UCT) and has access to associated biomarker networks like TRON, Stratifyer, the Immunological Research labs and several pathology departments etc.

Four treatment rooms with 3 beds each

A modern multi-purpose room

On site lab for clinical diagnostics and adequate processing of trial materials and specimen

Mobile IT, ultrasound and ECG equipment

Modern standard emergency equipment

In-house emergency care and both medical and surgical intensive care units

24 hours resuscitation team on duty

In-house pharmacy, institutes of radiology and interventional radiology, neuroradiology and pathology, departments for oncology and radiation oncology, central lab, endoscopy and interventional endoscopy

Network, Partners, and Supporters

For the conduct of our phase II and phase III studies, we coordinate a national network of more than 300 medical centers and partner powerful academic research groups such as the German Gastric Group at AIO (FLOT study group) (German Cancer Society), the German Rectum Study Group and others.

Our services include phase I and IIa trials as well as phase III and IV trials. In tight collaboration with our partners, the Northwest Hospital and the University Cancer Center (UCT) Frankfurt, one of the major medical centers for cancer research and treatment in Germany, we provide a modern phase I unit, fully dedicated to cancer studies and special expertise in pre-clinical and early clinical research.

Long - term collaborations

UCT – University Cancer Center Frankfurt

Medical Oncology Working Group of the German Cancer Society

Northwest Hospital

Thoraxklinik of the University Hospital Heidelberg

Our trials supported by

IKF Clinical cancer research GmbH
am Krankenhaus Nordwest
Steinbacher Hohl 2-26

60488 Frankfurt am Main
Germany
Tel +49 69 76 01 44 20
Fax +49 69 76 01 36 55
E-Mail: info.ikf@khnw.de

© 2019 IKF Clinical cancer research GmbH

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